Research

An overview of the questions, methods, and projects that define our lab's work.

Ten Core Research Areas

Core themes currently under investigation in the lab.

Fernandez-Lima Lab research areas overview: 01 Imaging MS (3D single-cell MS, MALDI tissue MS, FFPE tissue MS), 02 Protein-Protein & Protein-DNA (bottom-up, middle-down, top-down, HDX screening), 03 Epigenetics/PTMs (histones, DNA, RNA), 04 Metabolomics (hormones, metabolites), 05 Lipidomics (glycerolipids, phospholipids, sphingolipids, sterols, saccharolipids), 06 Drug Screening (prescription drugs, opioids, cannabinoids, amphetamines), 07 Trace Analysis (explosives, drug metabolites), 08 Environmental Resilience (crude oils, dissolved organic matter), 09 Forever Contaminants & Discovery (PAHs, PFAS, PCBs), 10 Outreach (seminars, open house, hands-on demos, summer fellowships).

Research Grants

Current and past extramural funding supporting the lab's work, per Prof. Fernandez-Lima's ORCID record.

Development of biological structural tools for the study of protein-DNA complexes

Active NIH · NIGMS R35GM153450 2024–2029

Development of Multidimensional Ion Mobility-Tandem Mass Spectrometry (IMSⁿ-FT-ICR MSⁿ) Tools for the Characterization of Complex Mixtures

Active NSF · Div. of Chemistry 2304837 2023–2026

CREST Phase II: Center for Aquatic Chemistry and Environment (CAChE)

Active NSF · STEM Education 2111661 2021–2026

How can mosquitoes develop and reproduce in the complete absence of juvenile hormone?

NIH · NIAID R21AI167849 2022–2024

Development of Multidimensional, Linear and Differential Ion Mobility MS Separations for Middle-Down Proteoforms

NIH · NIGMS R01GM134247 2019–2024

Understanding mosquito ovary dynamics and reproductive fitness using Mass Spectrometry Imaging

NIH · NIAID R21AI135469 2018–2022

CAREER: Development of Gas-phase, Post-ionization Structural Tools for the Study of DNA-protein Complexes

NSF · Div. of Chemistry 1654274 2017–2023

Mass Spectrometry Based Molecular Imaging of Native Biological Nanodomains

NIH · NIGMS R00GM106414 2010–2016

Mass Spectrometry Based Molecular Imaging of Native Biological Nanodomains

NIH · NCATS K99RR030188 2010–2012

Current Projects

Active projects and their status.

Project Alpha

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Project Beta

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Project Gamma

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